The BD PhaSeal™ OPtima system

The Most Widely Published CSTD In The World

What is the BD PhaSeal™ Optima System?

A closed system drug transfer device (CSTD) that has been demonstrated to prevent exposure to hazardous drugs, from drug preparation to IV administration and disposal.

Innovation to Protect Healthcare Workers

About 8 million U.S. healthcare workers are potentially exposed to hazardous drugs, including pharmacists, nursing personnel, physicians…1

1- HAZARDOUS DRUG EXPOSURES IN HEALTHCARE, NIOSH,2020

Exposure to hazardous drugs can result in adverse health effects in healthcare workers.

Detrimental Effect on DNA

Detrimental Effect on DNA

Pharmacists and nurses who handle antineoplastic drugs show a 2.5-fold increase in total chromosomal aberrations (CAs), with up to a 5-fold increase in certain CA types1,2

Damage to Internal Organs

Damage to Internal Organs

Three consecutive head nurses handling cytostatic agents had liver damage.5

Reproductive Problems

Reproductive Problems

Nurses who handle cancer drugs have children with 70% more birth defects and have a 14% higher risk of miscarriage.6

Increases Rate of Cancer

Increases Rate of Cancer

This includes relative risk of leukemia increases for oncology nurses.3 , and a 2.8-times increase in non-melanoma skin cancer and a 3.7-times increase in non-Hodgkin’s lymphoma in pharmacy techs4

Harm to Developing Fetuses

Harm to Developing Fetuses

Handling cytostatic drugs was associated with malformations in offspring.7

1 Cavallo D, Ursini CL, Perniconi B, et al. Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat Res. 2005;587(1-2):45-51.
2 McDiarmid MA, Oliver MS, Roth TS, Rogers B, Escalante C. Chromosome 5 and 7 abnormalities in oncology personnel handling an-ticancer drugs. J Occup Environ Med. 2010;52(10):1028-34.
3 Skov T, Maarup B, Olsen J, et al. Leukaemia and reproductive outcome among nurses handling antineoplastic drugs. Br J Ind Med. 1992;49(12):855-861.
4 Hansen J, Olsen JH. Cancer morbidity among Danish female pharmacy technicians. Scand J Work Environ Health. 1994;20(1):22-26.

5 Sotaniemi EA, Sutinen S, Arranto AJ, et al. Liver damage in nurses handling cytostatic agents. Acta Med Scand.
6 Nurses’ Health and Workplace Exposures to Hazardous Substances. Study conducted by Environmental Working Group, Health Care Without Harm, American Nurses Association, Environ mental Health Education Center at University of Maryland School of Nursing. Environmental Working Group website http://www.ewg.org/research/nurses-health/nurses-exposure. Published December 11, 2007. Accessed January 24, 2017.
7 Hemminki K, Kyronen P, Lindbohm ML. Spontaneous abortions and malformations in the offspring of nurses exposed to anesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. J Epidemiol Community Health. 1985;39(2):141-147.

It is an airtight, leakproof system that utilizes a membrane-to-membrane technology.

Efficient Hazardous Workflow

Helps improve workflow efficiency for the preparation of hazardous drugs

Faster Drug Turnaround

Helps improve the turnaround time of hazardous drug preparation

Contamination-Free Drug Handling

– Mechanically prohibits the transfer of environmental contaminants into the system and the escape of drug or vapor concentrations outside the system, thereby minimizing individual and environmental exposure to drug vapor aerosols and spills
– Prevents microbial ingress so sterility of vial contents may remain unaffected for up to 168 hours

Improved Drug Utilization

– May enable better utilization of drugs in short supply when used as part of your drug vial optimization program
– May help reduce drug waste as part of your drug vial optimization program

The BD PhaSeal System is supported by peer-reviewed studies and academic posters.

Recommended by:
  • ASHP (American Society of health- system Pharmacists)
  • USP (United States Pharmacopeia) <800> mandates CSTD for administration​
  • NIOSH (National institute for occupational safety and health)
  • OSHA (Occupational safety and health administration)
  • ONS (Oncology nursing society)

All of these components are important and complement each other in order to ensure that the system is totally closed and there is no leakage of aerosols or spills.

PhaSeal Equipment Needed to Ensure a Closed System:

Injector Luer lock N35

Injector Luer lock N35

o The Injector Luer Lock attaches to a standard syringe or IV line for a dry, leakproof connection during drug preparation and administration.
o It ensures a closed drug transfer by means of tightly sealed, double elastomeric membranes
o Can be used up to 10 times
Protector

Protector

o A pressure equalization device that is permanently attached to the vial and is used in the preparation of either powder or liquid drugs.
o Provides airtight safety due to the sealed expansion chamber and dry leakproof connections
o One protector per vial
The protectors can fit different sizes of vials available
Connector Luer lock C35

Connector Luer lock C35

o The Connector is the access port for closed administration of hazardous drugs during injections and infusions.
o It attaches to standard Luer Lock ports and seals these due to the unique membrane design
Infusion Adapter C100

Infusion Adapter C100

Connection between IV bag and non-vented infusion set. Built-in BD PhaSeal. Connector for closed transfer to IV bag